![]() ![]() 5 Betaine (also known as trimethylglycine, or TMG), magnesium, and the trace mineral lithium are also involved in maintaining homocysteine balance. 4 Omega-3 fatty acids may complement B vitamins in encouraging efficient metabolism of homocysteine. 1 People with a genetic propensity for higher homocysteine levels may especially benefit from supplementing with B 2, folate, B 6, and B 12. 3Īdequate intake of the B vitamins folate (B 9), cobalamin (B 12), pyridoxine (B 6), and riboflavin (B 2) helps facilitate healthy breakdown of homocysteine. This is especially true in the context of cardiovascular and neurological health. ![]() 2,3 Although the degree of causality attributable to homocysteine in these conditions is debated, maintaining a healthy homocysteine level is an important part of an overall healthy lifestyle. 1 High homocysteine levels have been correlated with a range of health problems, including atherosclerosis, stroke, neurological diseases, diabetes complications, osteoporosis, depression, erectile dysfunction, and pregnancy complications. In healthy circumstances, homocysteine is rapidly broken down, but genetic factors, nutritional inadequacies, certain medications, and some medical conditions can lead to excess homocysteine accumulation, which can damage blood vessels. Homocysteine is an amino acid made in the body through metabolism of the essential amino acid methionine. Taurine: Research suggests taurine can block methionine absorption (which is converted to homocysteine in the body) and produce a significant decline in homocysteine levels in 4 weeks.S-adenosylmethionine (SAMe): Supplementing with SAMe promotes the conversion of homocysteine to cysteine, which is then converted to glutathione and lowers homocysteine levels.N-acetylcysteine (NAC): NAC may displace homocysteine from its protein carrier, which lowers homocysteine and promotes the formation of cysteine and glutathione, a powerful antioxidant.Betaine (TMG) and choline: Higher intakes of TMG and choline (which is converted to TMG in the body) are related to lower circulating homocysteine concentrations.The active form of folate, L-methylfolate, can achieve plasma folate levels up to 700% higher than synthetic folic acid and therefore may be more effective at lowering homocysteine levels. B vitamins: Folate, along with vitamins B 6 and B 12, has been shown in numerous studies to help lower homocysteine levels.Decrease or eliminate alcohol and smoking.Exercise, as patients in a cardiac rehabilitation program showed a reduction in homocysteine from exercise alone.Avoid methionine-rich foods like red meat and dairy products.Several dietary and lifestyle changes can help reduce chronic inflammation: Note: Life Extension believes that the optimal range for homocysteine levels is <8 µmol/L, much lower than the currently accepted <15 µmol/L. Genetic variant that causes an impaired ability to metabolize active folate from folic acid.High-methionine diet (including red meat and dairy products).Certain prescription drugs (including cholestyramine, colestipol, fenofibrate, levodopa, metformin, methotrexate, high-dose niacin, nitrous oxide, pemetrexed, phenytoin, sulfasalazine).Insufficient folate, vitamin B 6, vitamin B 12, betaine, vitamin B 2, and magnesium.Many factors contribute to high homocysteine levels: Causes of High Homocysteine Levels (Hyperhomocysteinemia) Elevated levels of homocysteine have been associated with many diseases, including:įortunately, B vitamins like folate, vitamins B 6and B 12, and other integrative interventions can reduce homocysteine and counteract this destructive process. Homocysteine is an amino acid made from a common dietary amino acid, methionine, that inflicts damage to the inner arterial lining (endothelium). ![]()
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